diff --git a/src/wp-includes/block-supports/aria-label.php b/src/wp-includes/block-supports/aria-label.php
index aa559bcacd967..b51cd3499e0d4 100644
--- a/src/wp-includes/block-supports/aria-label.php
+++ b/src/wp-includes/block-supports/aria-label.php
@@ -49,7 +49,10 @@ function wp_apply_aria_label_support( $block_type, $block_attributes ) {
 	}
 
 	$has_aria_label_support = block_has_support( $block_type, array( 'ariaLabel' ), false );
-	if ( ! $has_aria_label_support ) {
+	if (
+		! $has_aria_label_support ||
+		wp_should_skip_block_supports_serialization( $block_type, 'ariaLabel' )
+	) {
 		return array();
 	}
 
diff --git a/tests/phpunit/tests/block-supports/aria-label.php b/tests/phpunit/tests/block-supports/aria-label.php
index 087f4843cebb0..93666ba0fb493 100644
--- a/tests/phpunit/tests/block-supports/aria-label.php
+++ b/tests/phpunit/tests/block-supports/aria-label.php
@@ -44,15 +44,16 @@ private function register_aria_label_block_with_support( $block_name, $supports
 	}
 
 	/**
-	 * Tests that position block support works as expected.
+	 * Tests that aria-label block support works as expected.
 	 *
 	 * @ticket 62919
+	 * @ticket 64594
 	 *
 	 * @dataProvider data_aria_label_block_support
 	 *
 	 * @param boolean|array $support  Aria label block support configuration.
 	 * @param string        $value    Aria label value for attribute object.
-	 * @param array         $expected Expected aria label block support styles.
+	 * @param array         $expected Expected aria-label attributes.
 	 */
 	public function test_wp_apply_aria_label_support( $support, $value, $expected ) {
 		$block_type  = self::register_aria_label_block_with_support(
@@ -82,6 +83,13 @@ public function data_aria_label_block_support() {
 				'value'    => 'Label',
 				'expected' => array(),
 			),
+			'aria-label attribute is not applied when serialization is skipped' => array(
+				'support'  => array(
+					'__experimentalSkipSerialization' => true,
+				),
+				'value'    => 'Label',
+				'expected' => array(),
+			),
 		);
 	}
 }